mAb anti-Human α-Synuclein, 4C1

Description

Description: Mouse monoclonal antibody to human α-synuclein

Purification: Protein G affinity purified

Product Type: Primary antibody

Target Protein: Human α-synuclein

Immunogen: Recombinant human α-synuclein (1-140 aa) expressed in E. coli.

Fusion Myeloma: Sp2/0-Ag14

Specificity: This antibody recognizes human α-synuclein epitope YQDYEP(E). 

Species Reacitvity: Human

Host / Isotype: Mouse, IgG2a Kappa

Formulation: Lyophilized from a solution in 0.01M PBS pH7.2

Reconstitution: Double distilled water is recommended to adjust the final concentration to 1.00mg/mL. 

Storage: Store at -20^oC

Research Area: Parkinson’s disease, neurodegenerative diseases

Background:  

α-synuclein is a protein of unknown function.  It is mainly found in neural tissue. There is a lipid-binding motif similar to that of Apolipoproteins on its N-terminal.  A hydrophobic region that is the non-beta component found in amyloid aggregation in Alzheimer’s disease is located at the central region of the protein.  The abnormal aggregation of α-synuclein on brain tissue is called Lewy bodies, which are found in Parkinson’s disease, dementia and multiply system atrophy.  Mutated α-synuclein gene is found to be associated with rare familial form of Parkinson’s disease.

Application: 

ELISA: The antibody reacts with recombinant α-synuclein. 

Western Blot: Detect recombinant α- synuclein (α-SYN) using antibody 4C1 at 5μg/mL dilution.

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.